Inflammatory and autoimmune complications of common variable immune deficiency

被引：130

作者：

Knight, AK ^{[1
]}

Cunningham-Rundles, C ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, New York, NY 10029 USA

来源：

AUTOIMMUNITY REVIEWS | 2006年 / 5卷 / 02期

关键词：

common variable immune deficiency; autoimmunity; idiopathic thrombocytopenia purpura; hemolytic anemia;

D O I：

10.1016/j.autrev.2005.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Common variable immune deficiency (CVID) is associated with autoimmune and inflammatory complications in addition to recurrent infections. The most common conditions are idiopathic thrombocytopenia purpura, autoimmune hemolytic anemia, sarcoid-like granulomatous disease and gastrointestinal inflammation. IVIG administration reduces the frequency of infections, but does not always prevent autoimmunity or inflammation. TNF antagonists and anti-CD20 immunomodulators have shown some efficacy in CVID in a few patients; further controlled studies are needed to determine the best management of these conditions in the setting of immunodeficiency. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：156 / 159

页数：4

共 27 条

[1]

Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency-possible immunologic and clinical consequences [J].