Cytoplasmic tails of bunyavirus Gn glycoproteins-Could they act as matrix protein surrogates?

被引：39

作者：

Strandin, Tomas ^{[1
]}

Hepojoki, Jussi ^{[1
]}

Vaheri, Antti ^{[1
]}

机构：

[1] Univ Helsinki, Haartman Inst, Dept Virol, FI-00014 Helsinki, Finland

来源：

VIROLOGY | 2013年 / 437卷 / 02期

基金：

芬兰科学院;

关键词：

Family Bunyaviridae; Hantavirus; Tospovirus; Nairovirus; Orthobunyavirus; Phlebovirus; Cytoplasmic tail of Gn; Matrix protein; Budding; Assembly; VESICULAR-STOMATITIS-VIRUS; ARENAVIRUS Z-PROTEIN; RESPIRATORY SYNCYTIAL VIRUS; LATE BUDDING DOMAINS; VIRAL-RNA SYNTHESIS; VALLEY FEVER VIRUS; FINGER Z-PROTEIN; HOST PROTEINS; M1; PROTEIN; TRANSCRIPTION-INHIBITION;

D O I：

10.1016/j.virol.2013.01.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Viruses of the family Bunyaviridae are negative-sense RNA viruses (NRVs). Unlike other NRVs bunyaviruses do not possess a matrix protein, which typically facilitates virus release from host cells and acts as an anchor between the viral membrane and its genetic core. Therefore the functions of matrix protein in bunyaviruses need to be executed by other viral proteins. In fact, the cytoplasmic tail of glycoprotein Gn (Gn-CT) of various bunyaviruses interacts with the genetic core (nucleocapsid protein and/or genomic RNA). In addition the Gn-CT of phleboviruses (a genus in the family Bunyaviridae) has been demonstrated to be essential for budding. This review brings together what is known on the role of various bunyavirus Gn-CTs in budding and assembly, and hypothesizes on their yet unrevealed functions in viral life cycle by comparing to the matrix proteins of NRVs. (C) 2013 Elsevier Inc. All rights reserved.

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页码：73 / 80

页数：8

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