Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V

被引：6

作者：

Nakagawa, Y

Irie, K

Nakamura, Y

Ohigashi, H

Hayashi, H

机构：

[1] KYOTO UNIV, GRAD SCH AGR, DIV APPL LIFE SCI, SAKYO KU, KYOTO 606, JAPAN

[2] UNIV OSAKA PREFECTURE, FAC AGR, DEPT APPL BIOCHEM, SAKAI, OSAKA 593, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 08期

关键词：

conformation; (-)-indolactam-V; indolactone-V; protein kinase C; teleocidin; tumor promoter;

D O I：

10.1271/bbb.61.1415

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor promoter (-)-indolactam-V (1) exists in two stable conformers (twist and sofa) due to isomerization of the amide group, Indolactone-V (2), the lactone analogue of 1, has been synthesized to investigate the effects of the amide group on its conformation and biological activities. Indolactone-V (2) existed only as the inactive sofa-like conformer, indicating that the amide group of 1 plays a critical role in formation of the active twist conformation.

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页码：1415 / 1417

页数：3

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