Transcallosal bands: A sign of neuronal tract degeneration in early MS?

被引：17

作者：

Simon, JH

Jacobs, L

Kinkel, RP

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Radiol MRI, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Radiol Neuroradiol, Denver, CO 80262 USA

[3] Buffalo Gen Hosp, Buffalo, NY 14203 USA

[4] Cleveland Clin Fdn, Cleveland, OH 44195 USA

来源：

NEUROLOGY | 2001年 / 57卷 / 10期

关键词：

D O I：

10.1212/WNL.57.10.1888

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A pattern of injury observed in patients at high risk for MS described as transcallosal bands (TCB) is hypothesized to be the result of neuronal tract degeneration in earliest MS, extending from typical acute, focal demyelinating lesions located along the lateral borders of the corpus callosum. The TCB, a T2-hyperintense lesion traversing the corpus callosum is recognized on 3-mm. thick, T2-weighted imaging, develops over months and persists over years.

引用

页码：1888 / 1890

页数：3

共 11 条

[1] Proton MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis [J].

Brex, PA ;

Gomez-Anson, B ;

Parker, GJM ;

Molyneux, PD ;

Miszkiel, KA ;

Barker, GJ ;

MacManus, DG ;

Davie, CA ;

Plant, GT ;

Miller, DH .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1999, 166 (01) :16-22

[2]

COWLEY AR, 1983, AM J NEURORADIOL, V4, P915

[3] In vivo evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis [J].

De Stefano, N ;

Narayanan, S ;

Matthews, PM ;

Francis, GS ;

Antel, JP ;

Arnold, DL .

BRAIN, 1999, 122 :1933-1939

[4]

Evangelou N, 2000, ANN NEUROL, V47, P391, DOI 10.1002/1531-8249(200003)47:3<391::AID-ANA20>3.3.CO

[5]

2-A

[6]

Filippi M, 1999, MULT SCLER J, V5, P273

[7] Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. [J].

Jacobs, LD ;

Beck, RW ;

Simon, JH ;

Kinkel, RP ;

Brownscheidle, CM ;

Murray, TJ ;

Simonian, NA ;

Slasor, PJ ;

Sandrock, AW .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (13) :898-904

[8]

Simon JH, 2000, NEUROIMAG CLIN N AM, V10, P753

[9] A Wallerian degeneration pattern in patients at risk for MS [J].

Simon, JH ;

Kinkel, RP ;

Jacobs, L ;

Bub, L ;

Simonian, N .

NEUROLOGY, 2000, 54 (05) :1155-1160

[10] Axonal transection in the lesions of multiple sclerosis [J].

Trapp, BD ;

Peterson, J ;

Ransohoff, RM ;

Rudick, R ;

Mörk, S ;

Bö, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (05) :278-285

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