Genetics of inflammatory bowel diseases: A comparison between Western and Eastern perspectives

被引：44

作者：

Cheon, Jae Hee ^{[1
,2
,3
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul 120752, South Korea

[3] Yonsei Univ, Brain Korea Project Med Sci 21, Seoul 120752, South Korea

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2013年 / 28卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Crohn's disease; epigenetics; genetics; immunomodulator; inflammatory bowel disease; ulcerative colitis; GENOME-WIDE ASSOCIATION; INOSINE TRIPHOSPHATE PYROPHOSPHATASE; CROHNS-DISEASE; THIOPURINE METHYLTRANSFERASE; ULCERATIVE-COLITIS; BEHCETS-DISEASE; KOREAN PATIENTS; CONFER SUSCEPTIBILITY; FAMILIAL OCCURRENCE; JAPANESE PATIENTS;

D O I：

10.1111/jgh.12053

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Inflammatory bowel disease (IBD) is a chronic relapsing intestinal inflammatory disorder with unidentified causes. Currently, studies indicate that IBD results from a complex interplay between various genetic and environmental factors that produce intestinal inflammation. However, these factors may differ for Asians and Caucasians. Thus, differences in epidemiology, genetic variants, and clinical phenotypes of IBD have been observed between the two populations. Understanding the discrepancies between data from populations with different genetic backgrounds and environmental factors may reveal fundamental aspects of IBD pathogenesis. Accordingly, this review will summarize the current knowledge of IBD genetics studied in Asian countries and compare it with that from Western countries, with special focus on innate bacterial sensing, autophagy, and the interleukin-23 receptor-T helper cell 17 pathway. The epigenetic nature of IBD pathogenesis as well as the pharmacogenetics related to the use of immunomodulators will also be briefly covered.

引用

页码：220 / 226

页数：7

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