Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

被引:498
作者
Carmeliet, P [1 ]
Ng, YS
Nuyens, D
Theilmeier, G
Brusselmans, K
Cornelissen, I
Ehler, E
Kakkar, VV
Stalmans, I
Mattot, V
Perriard, JC
Dewerchin, M
Flameng, W
Nagy, A
Lupu, F
Moons, L
Collen, D
D'Amore, PA
Shima, DT
机构
[1] Katholieke Univ Leuven VIB, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium
[2] Harvard Univ, Sch Med, Schepens Eye Res Inst, Boston, MA 02115 USA
[3] Swiss Fed Inst Technol, Inst Cell Biol, CH-8093 Zurich, Switzerland
[4] Thrombosis Res Inst, Weston Expt Res Ctr, Vasc Biol Lab, London SW3 6LR, England
[5] Katholieke Univ Leuven, Lab Expt Cardiac Surg, B-3000 Louvain, Belgium
[6] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5 1X5, Canada
[7] Imperial Canc Res Fund, London WC2A 3PX, England
关键词
D O I
10.1038/8379
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:495 / 502
页数:8
相关论文
共 46 条
[1]   MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure [J].
Arber, S ;
Hunter, JJ ;
Ross, J ;
Hongo, M ;
Sansig, G ;
Borg, J ;
Perriard, JC ;
Chien, KR ;
Caroni, P .
CELL, 1997, 88 (03) :393-403
[2]   Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat [J].
Ausma, J ;
Wijffels, M ;
Thone, F ;
Wouters, L ;
Allessie, M ;
Borgers, M .
CIRCULATION, 1997, 96 (09) :3157-3163
[3]  
Borgers Marcel, 1997, P287
[4]   Role of HIF-1α or in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis [J].
Carmeliet, P ;
Dor, Y ;
Herbert, JM ;
Fukumura, D ;
Brusselmans, K ;
Dewerchin, M ;
Neeman, M ;
Bono, F ;
Abramovitch, R ;
Maxwell, P ;
Koch, CJ ;
Ratcliffe, P ;
Moons, L ;
Jain, RK ;
Collen, D ;
Keshet, E .
NATURE, 1998, 394 (6692) :485-490
[5]   Role of tissue factor in embryonic blood vessel development [J].
Carmeliet, P ;
Mackman, N ;
Moons, L ;
Luther, T ;
Gressens, P ;
VanVlaenderen, I ;
Demunck, H ;
Kasper, M ;
Breier, G ;
Evrard, P ;
Muller, M ;
Risau, W ;
Edgington, T ;
Collen, D .
NATURE, 1996, 383 (6595) :73-75
[6]   Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele [J].
Carmeliet, P ;
Ferreira, V ;
Breier, G ;
Pollefeyt, S ;
Kieckens, L ;
Gertsenstein, M ;
Fahrig, M ;
Vandenhoeck, A ;
Harpal, K ;
Eberhardt, C ;
Declercq, C ;
Pawling, J ;
Moons, L ;
Collen, D ;
Risau, W ;
Nagy, A .
NATURE, 1996, 380 (6573) :435-439
[7]   Myocardial cell death and apoptosis in hibernating myocardium [J].
Chen, CG ;
Ma, LJ ;
Linfert, DR ;
Lai, TJ ;
Fallon, JT ;
Gillam, LD ;
Waters, DD ;
Tsongalis, GJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 30 (05) :1407-1412
[8]   Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF(121) and VEGF(165) but not VEGF(189) [J].
Cheng, SY ;
Nagane, M ;
Huang, HJS ;
Cavenee, WK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) :12081-12087
[9]   Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon [J].
Cheung, N ;
Wong, MP ;
Yuen, ST ;
Leung, SY ;
Chung, LP .
HUMAN PATHOLOGY, 1998, 29 (09) :910-914
[10]  
DVORAK HF, 1995, AM J PATHOL, V146, P1029