Enantioselective synthesis of alpha-phosphinoketones

被引：12

作者：

Enders, D

Berg, T

Raabe, G

Runsink, J

机构：

来源：

HELVETICA CHIMICA ACTA | 1996年 / 79卷 / 01期

关键词：

D O I：

10.1002/hlca.19960790112

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first asymmetric (C-P)-connective synthesis of alpha-phosphinoketones in high enantiomeric purity (e.e. 91-97 %) is described. Key step is the highly diastereoselective phosphinylation of SAMP-hydrazones (S)-2 to produce alpha-phosphinohydrazones (S,R)-3, isolated as the more stable borane adducts. Subsequent ozonolysis afforded the title compounds (R)-4, potential ligands for enantioselective homogeneous catalysis.

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页码：118 / 122

页数：5

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