Neutrophils in acute kidney injury: not neutral any more

被引：102

作者：

Bolisetty, Subhashini ^{[1
]}

Agarwal, Anupam ^{[1
]}

机构：

[1] Univ Alabama, Div Nephrol, Ctr Nephrol Res & Training, Birmingham, AL 35294 USA

来源：

KIDNEY INTERNATIONAL | 2009年 / 75卷 / 07期

基金：

美国国家卫生研究院;

关键词：

ACUTE-RENAL-FAILURE; ACUTE TUBULAR-NECROSIS; REPERFUSION INJURY; IMMUNE-RESPONSE; MECHANISMS; RECEPTORS; BLOCKING; ADHESION; PROTECTS;

D O I：

10.1038/ki.2008.689

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Awad and colleagues elucidate the spatiotemporal profile of neutrophil infiltration in the kidney following ischemia-reperfusion injury. Using elegant in vivo labeling techniques, they demonstrate increased neutrophil content in the kidney following ischemia-reperfusion, which is largely due to transmigration from the circulation into the interstitial compartment. The authors also provide mechanistic insights into this phenomenon and show that adenosine 2A receptor agonists reduce interstitial neutrophil infiltration and improve renal function.

引用

页码：674 / 676

页数：4

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