The aging kidney

被引：278

作者：

Zhou, Xin J. ^{[1
,2
]}

Rakheja, Dinesh ^{[1
]}

Yu, Xueqing ^{[3
]}

Saxena, Ramesh ^{[2
]}

Vaziri, Nosratola D. ^{[4
]}

Silva, Fred G. ^{[5
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Med, Dallas, TX 75390 USA

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Peoples R China

[4] Univ Calif Irvine, Dept Med, Div Nephrol & Hypertens, Irvine, CA 92717 USA

[5] United States & Canadian Acad Pathol, Augusta, GA USA

来源：

KIDNEY INTERNATIONAL | 2008年 / 74卷 / 06期

关键词：

senescence; pathology; kidney transplantation; oxidative stress; molecular mechanism; pathophysiology;

D O I：

10.1038/ki.2008.319

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Renal aging, by itself, is associated with alterations in renal morphology and a decline in renal function, which is accelerated and/or accentuated by diseases such as diabetes mellitus and hypertension. The aging-related renal insufficiency has important implications with regards to body homeostasis, drug toxicity, and renal transplantation. An understanding of renal aging and its distinction from renal insufficiency secondary to diseases is essential for individualized care of the elderly. Toward this end, investigations are underway to elucidate the molecular mechanisms of renal aging. This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in our understanding of the renal aging process.

引用

页码：710 / 720

页数：11

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