Osteonecrosis of femoral head in the stroke-prone spontaneously hypertensive rats, especially old rats

被引：11

作者：

Suzuki, Masahiko ^{[1
]}

Kumagai, Kenji ^{[1
]}

Osaki, Makoto ^{[1
]}

Murata, Masakazu ^{[1
]}

Tomita, Masato ^{[1
]}

Miyata, Noriaki ^{[1
]}

Hozumi, Akira ^{[1
]}

Niwa, Masami ^{[2
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Orthoped Surg, Nagasaki 852, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pharmacol, Nagasaki 852, Japan

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2008年 / 30卷 / 07期

关键词：

SHRSP; idiopathic osteonecrosis of the femoral head; old rats;

D O I：

10.1080/10641960802251883

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The average life span of stroke-prone spontaneously hypertensive rats (SHRSP) is about eight months. Male SHRSPs at 40 weeks old were used to study the idiopathic osteonecrosis of the femoral head (ION). The control group showed about 40% old necrosis and 20% early necrosis. The group administered with steroid hormone showed an increasing degeneration of adipocyte in the bone marrow, and 20% fresh necrosis was recognized. Furthermore, we observed the adipocyte change as well as early necrosis occurring among old necrosis sites. The study of aged rats may provide further understanding into the pathogenesis of ION.

引用

页码：689 / 697

页数：9

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