PARKINSON DISEASE Laying the foundations for disease-modifying therapies in PD

被引：9

作者：

Brundin, Patrik ^{[1
]}

Wyse, Richard ^{[2
]}

机构：

[1] Van Andel Res Inst, Ctr Neurodegenerat Sci, Translat Parkinsons Dis Res, Grand Rapids, MI 49503 USA

[2] Cure Parkinsons Trust, London W1U 6TU, England

来源：

NATURE REVIEWS NEUROLOGY | 2015年 / 11卷 / 10期

关键词：

PIOGLITAZONE; EXPOSURE;

D O I：

10.1038/nrneurol.2015.150

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The results of a futility trial, which used the PPAR-gamma receptor agonist pioglitazone in an attempt to modify disease progression in Parkinson disease, do not support initiation of further trials. However, although this trial was well designed and conducted, we question whether it is time to fully shut the door on pioglitazone.

引用

页码：553 / 554

页数：2

共 9 条

[1]

Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson's Disease [J].

Aviles-Olmos, Iciar ;

Dickson, John ;

Kefalopoulou, Zinovia ;

Djamshidian, Atbin ;

Kahan, Joshua ;

Ell, Peter ;

Whitton, Peter ;

Wyse, Richard ;

Isaacs, Tom ;

Lees, Andrew ;

Limousin, Patricia ;

Foltynie, Thomas .

JOURNAL OF PARKINSONS DISEASE, 2014, 4 (03) :337-344

[2]

Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease [J].

Berg, Daniela ;

Postuma, Ronald B. ;

Bloem, Bastiaan ;

Chan, Piu ;

Dubois, Bruno ;

Gasser, Thomas ;

Goetz, Christopher G. ;

Halliday, Glenda M. ;

Hardy, John ;

Lang, Anthony E. ;

Litvan, Irene ;

Marek, Kenneth ;

Obeso, Jose ;

Oertel, Wolfgang ;

Olanow, C. Warren ;

Poewe, Werner ;

Stern, Matthew ;

Deuschl, Guenther .

MOVEMENT DISORDERS, 2014, 29 (04) :454-462

[3]

Glitazone Treatment and Incidence of Parkinson's Disease among People with Diabetes: A Retrospective Cohort Study [J].

Brauer, Ruth ;

Bhaskaran, Krishnan ;

Chaturvedi, Nishi ;

Dexter, David T. ;

Smeeth, Liam ;

Douglas, Ian .

PLOS MEDICINE, 2015, 12 (07)

[4]

Linked Clinical Trials - The Development of New Clinical Learning Studies in Parkinson's Disease Using Screening of Multiple Prospective New Treatments [J].

Brundin, Patrik ;

Barker, Roger A. ;

Conn, P. Jeffrey ;

Dawson, Ted M. ;

Kieburtz, Karl ;

Lees, Andrew J. ;

Schwarzschild, Michael A. ;

Tanner, Caroline M. ;

Isaacs, Tom ;

Duffen, Joy ;

Matthews, Helen ;

Wyse, Richard K. H. .

JOURNAL OF PARKINSONS DISEASE, 2013, 3 (03) :231-239

[5]

PPAR-γ: Therapeutic Prospects in Parkinson's Disease [J].

Carta, Anna R. .

CURRENT DRUG TARGETS, 2013, 14 (07) :743-751

[6]

Pioglitazone and bladder cancer risk: a multipopulation pooled, cumulative exposure analysis [J].

Levin, Daniel ;

Bell, Samira ;

Sund, Reijo ;

Hartikainen, Sirpa A. ;

Tuomilehto, Jaakko ;

Pukkala, Eero ;

Keskimaki, Ilmo ;

Badrick, Ellena ;

Renehan, Andrew G. ;

Buchan, Iain E. ;

Bowker, Samantha L. ;

Minhas-Sandhu, Jasjeet K. ;

Zafari, Zafar ;

Marra, Carlo ;

Johnson, Jeffrey A. ;

Stricker, Bruno H. ;

Uitterlinden, Andre G. ;

Hofman, Albert ;

Ruiter, Rikje ;

de Keyser, Catherine E. ;

MacDonald, Thomas M. ;

Wild, Sarah H. ;

McKeigue, Paul M. ;

Colhoun, Helen M. .

DIABETOLOGIA, 2015, 58 (03) :493-504

[7]

Review: The future of cell therapies and brain repair: Parkinson's disease leads the way [J].

Petit, G. H. ;

Olsson, T. T. ;

Brundin, P. .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2014, 40 (01) :60-70

[8]

Shared dysregulated pathways lead to Parkinson's disease and diabetes [J].

Santiago, Jose A. ;

Potashkin, Judith A. .

TRENDS IN MOLECULAR MEDICINE, 2013, 19 (03) :176-186

[9]

Simuni T, 2015, LANCET NEUROL, V14, P795, DOI 10.1016/S1474-4422(15)00144-1

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