NF-κB: Emerging roles in hippocampal development and function

被引：60

作者：

Crampton, Sean J. ^{[1
]}

O'Keeffe, Gerard W. ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Biosci Inst, Dept Anat & Neurosci, Cork, Ireland

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2013年 / 45卷 / 08期

基金：

爱尔兰科学基金会;

关键词：

Nuclear factor kappa-B; Hippocampus; Neurogenesis; Dendritic growth; Learning and memory; LONG-TERM-MEMORY; TRANSCRIPTION FACTOR; DENDRITIC SPINES; SYNAPTIC PLASTICITY; NEURITE GROWTH; IMMUNE-SYSTEM; IKK-EPSILON; PHOSPHORYLATION; ACTIVATION; KINASE;

D O I：

10.1016/j.biocel.2013.05.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The nuclear factor kappa-B family of transcription factors have been extensively studied in the immune system where they function to orchestrate the molecular response to immune challenge. However in recent years, members of this family have also been shown to play physiological roles in the development and function of the nervous system. The two best studied members of the nuclear factor kappa-B family are the p65 and the p50 proteins. In this review, we outline recent developments regarding the functions of these proteins in regulating hippocampal neurogenesis, neuronal growth and learning and memory and discuss the implications of their dysregulation during the development of the nervous system (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1821 / 1824

页数：4

共 40 条

[1]

c-Rel, an NF-κB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation [J].

Ahn, Hyung Jin ;

Hernandez, Caterina M. ;

Levenson, Jonathan M. ;

Lubin, Farah D. ;

Liou, Hsiou-Chi ;

Sweatt, J. David .

LEARNING & MEMORY, 2008, 15 (07) :539-549

[2]

FUNCTION AMD ACTIVATION OF NF-KAPPA-B IN THE IMMUNE-SYSTEM [J].

BAEUERLE, PA ;

HENKEL, T .

ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 :141-179

[3]

Activation of hippocampal nuclear factor-κB by retrieval is required for memory reconsolidation [J].

Boccia, Mariano ;

Freudenthal, Ramiro ;

Blake, Mariano ;

de la Fuente, Veronica ;

Acosta, Gabriela ;

Baratti, Carlos ;

Romano, Arturo .

JOURNAL OF NEUROSCIENCE, 2007, 27 (49) :13436-13445

[4]

A Requirement for Nuclear Factor-κB in Developmental and Plasticity-Associated Synaptogenesis [J].

Boersma, Matthew C. H. ;

Dresselhaus, Erica C. ;

De Biase, Lindsay M. ;

Mihalas, Anca B. ;

Bergles, Dwight E. ;

Meffert, Mollie K. .

JOURNAL OF NEUROSCIENCE, 2011, 31 (14) :5414-5425

[5]

Effects of prenatal infection on brain development and behavior: A review of findings from animal models [J].

Boksa, Patricia .

BRAIN BEHAVIOR AND IMMUNITY, 2010, 24 (06) :881-897

[6]

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-κB at serine 536 is mediated by multiple protein kinases including IκB kinase (IKK)-α, IKKβ, IKKε, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription [J].

Buss, H ;

Dörrie, A ;

Schmitz, ML ;

Hoffmann, E ;

Resch, K ;

Kracht, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (53) :55633-55643

[7]

NGF-activated protein tyrosine phosphatase 1B mediates the phosphorylation and degradation of I-κ-Bα coupled to NF-κ-B activation, thereby controlling dendrite morphology [J].

Chacon, Pedro J. ;

Angeles Arevalo, Maria ;

Rodriguez Tebar, Alfredo .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2010, 43 (04) :384-393

[8]

Impaired adult neurogenesis associated with short-term memory defects in NF-κB p50-deficient mice [J].

Denis-Donini, Suzanne ;

Dellarole, Anna ;

Crociara, Paola ;

Francese, Maria Teresa ;

Bortolotto, Valeria ;

Quadrato, Giorgia ;

Canonico, Pier Luigi ;

Orsetti, Marco ;

Ghi, Piera ;

Memo, Maurizio ;

Bonini, Sara Anna ;

Ferrari-Toninelli, Giulia ;

Grilli, Mariagrazia .

JOURNAL OF NEUROSCIENCE, 2008, 28 (15) :3911-3919

[9]

NF-κB transcription factor is required for inhibitory avoidance long-term memory in mice [J].

Freudenthal, R ;

Boccia, MM ;

Acosta, GB ;

Blake, MG ;

Merlo, E ;

Baratti, CM ;

Romano, A .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (10) :2845-2852

[10]

κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus [J].

Freudenthal, R ;

Locatelli, F ;

Hermitte, G ;

Maldonado, H ;

Lafourcade, C ;

Delorenzi, A ;

Romano, A .

NEUROSCIENCE LETTERS, 1998, 242 (03) :143-146

← 1 2 3 4 →