Natural polysaccharide carrageenan inhibits toxic effect of gram-negative bacterial endotoxins

被引：15

作者：

Ermak, I. M. ^{[1
]}

Barabanova, A. O.

Kukarskikh, T. A.

Solovyova, T. F.

Bogdanovich, R. N.

Polyakova, A. M.

Astrina, O. P.

Maleyev, V. V.

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far Eastern Div, Vladivostok 690022, Russia

[2] Minist Hlth Russian Federat, Cent Inst Epidemiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 02期

关键词：

lipopolysaccharide; carrageenan; toxicity; platelet aggregation;

D O I：

10.1007/s10517-006-0135-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The protective effect of polysaccharide carrageenan on the damaging effect of endotoxins of gram-negative bacteria was studied in vivo and in vitro. Carrageenan increased mouse resistance to the toxic effect of LPS. The degree of protection depended on polysaccharide concentration and administration time and route. Pretreatment of donor platelets with carrageenan reduced their aggregation activity caused by cooperative effect of LPS and ADP.

引用

页码：230 / 232

页数：3

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