Overcoming barriers to long-term graft survival

被引:28
作者
Kaplan, B [1 ]
机构
[1] Univ Illinois, Coll Med, Dept Med, Chicago, IL 60612 USA
关键词
kidney transplant; acute rejection; chronic allograft nephropathy (CAN); renal function; graft survival; immunosuppression; tacrolimus (TAC); cyclosporine (CsA); mycophenolate mofetil (MMF); sirolimus (SRL);
D O I
10.1053/j.ajkd.2005.12.044
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Although short-term kidney graft survival has improved in recent years, the focus has shifted to the challenge of improving long-term graft survival. Acute rejection, chronic allograft nephropathy, and cardiovascular disease are associated with graft loss and patient death. Reducing the potential for such posttransplantation complications may improve long-term graft survival. In addition, gaining a better understanding of the role that various immunosuppressive therapies have in decreasing the risk for graft injury will help clinicians make better-informed decisions about appropriate treatment regimens for individual kidney transplant recipients.
引用
收藏
页码:S52 / S64
页数:13
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