DNA methyltransferases get connected to chromatin

被引：116

作者：

Burgers, WA

Fuks, F

Kouzarides, T

机构：

[1] Univ Cape Town, Div Med Virol, Fac Hlth Sci, Sch Med, ZA-7925 Cape Town, South Africa

[2] Free Univ Brussels, Mol Virol Lab, Fac Med, Brussels, Belgium

[3] Wellcome CRC Inst, Dept Pathol, Cambridge CB2 1QR, England

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 06期

关键词：

D O I：

10.1016/S0168-9525(02)02667-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The DNA methyltransferases (Dnmts) are responsible for the generation of genomic methylation patterns, which lead to transcriptional silencing. Recent studies have identified new protein partners for the Dnmts revealing novel mechanisms by which they can be targeted to specific genomic regions to silence genes. In particular, the links identified with histone deacetylases, histone methyltransferases and SNF-2-like ATPases are defining new requirements for the functioning of Dnmts. A picture is emerging whereby the Dnmts are intimately connected to the chromatin environment in which they are working.

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页码：275 / 277

页数：3

相关论文

共 24 条

[1] Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family [J].

Aapola, U ;

Shibuya, K ;

Scott, HS ;

Ollila, J ;

Vihinen, M ;

Heino, M ;

Shintani, A ;

Kawasaki, K ;

Minoshima, S ;

Krohn, K ;

Antonarakis, SE ;

Shimizu, N ;

Kudoh, J ;

Peterson, P .

GENOMICS, 2000, 65 (03) :293-298

[2] Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin [J].

Bachman, KE ;

Rountree, MR ;

Baylin, SB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (34) :32282-32287

[3] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].

Bannister, AJ ;

Zegerman, P ;

Partridge, JF ;

Miska, EA ;

Thomas, JO ;

Allshire, RC ;

Kouzarides, T .

NATURE, 2001, 410 (6824) :120-124

[4] Methylation-induced repression - Belts, braces, and chromatin [J].

Bird, AP ;

Wolffe, AP .

CELL, 1999, 99 (05) :451-454

[5] Dnmt3L and the establishment of maternal genomic imprints [J].

Bourc'his, D ;

Xu, GL ;

Lin, CS ;

Bollman, B ;

Bestor, TH .

SCIENCE, 2001, 294 (5551) :2536-2539

[6]

Chua S, 1997, DIABETES REV, V5, P2

[7] Lsh, a member of the SNF2 family, is required for genome-wide methylation [J].

Dennis, K ;

Fan, T ;

Geiman, T ;

Yan, QS ;

Muegge, K .

GENES & DEVELOPMENT, 2001, 15 (22) :2940-2944

[8] Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor [J].

Di Croce, L ;

Raker, VA ;

Corsaro, M ;

Fazi, F ;

Fanelli, M ;

Faretta, M ;

Fuks, F ;

Lo Coco, F ;

Kouzarides, T ;

Nervi, C ;

Minucci, S ;

Pelicci, PG .

SCIENCE, 2002, 295 (5557) :1079-1082

[9] Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription [J].

Fuks, F ;

Burgers, WA ;

Godin, N ;

Kasai, M ;

Kouzarides, T .

EMBO JOURNAL, 2001, 20 (10) :2536-2544

[10] DNA methyltransferase Dnmt1 associates with histone deacetylase activity [J].

Fuks, F ;

Burgers, WA ;

Brehm, A ;

Hughes-Davies, L ;

Kouzarides, T .

NATURE GENETICS, 2000, 24 (01) :88-91