Minocycline: A Neuroprotective Agent for Hypoxic-Ischemic Brain Injury in the Neonate?

被引：63

作者：

Buller, Kathryn M. ^{[1
]}

Carty, Michelle L. ^{[1
]}

Reinebrant, Hanna E. ^{[1
]}

Wixey, Julie A. ^{[1
]}

机构：

[1] Univ Queensland, Clin Res Ctr, Perinatal Res Ctr, Herston, Qld 4029, Australia

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2009年 / 87卷 / 03期

关键词：

hypoxia-ischemia; minocycline; neonate; neuroinflammation; neuroprotection; INDUCED NEUROLOGICAL DYSFUNCTION; WHITE-MATTER INJURY; MATURATION-DEPENDENT VULNERABILITY; FOCAL CEREBRAL-ISCHEMIA; CYTOCHROME-C RELEASE; SPINAL-CORD-INJURY; LOW-BIRTH-WEIGHT; MICROGLIAL ACTIVATION; RAT-BRAIN; PERIVENTRICULAR LEUKOMALACIA;

D O I：

10.1002/jnr.21890

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Minocycline is a second-generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentious. Tetracyclines, as a class, are not usually administered to neonates, but there is compelling evidence that minocycline reduces brain injury after neonatal hypoxic-ischemic brain injury. This Review focuses on the evidence for minocycline use in neonates by considering aspects of pharmacology, drug regimens, functional outcomes, and mechanisms of action. (C) 2008 Wiley-Liss, Inc.

引用

页码：599 / 608

页数：10

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