Hachimi-jio-gan extract protects the kidney from hypertensive injury in Dahl salt-sensitive rat

被引：7

作者：

Hirawa, N ^{[1
]}

Uehara, Y ^{[1
]}

Kawabata, Y ^{[1
]}

Numabe, A ^{[1
]}

Takada, S ^{[1
]}

Nagoshi, H ^{[1
]}

Gomi, T ^{[1
]}

Ikeda, T ^{[1
]}

Omata, M ^{[1
]}

机构：

[1] KANTOH TEISHIN HOSP,DEPT NEPHROL,TOKYO,JAPAN

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 1996年 / 24卷 / 3-4期

关键词：

D O I：

10.1142/S0192415X9600030X

中图分类号：

R [医药、卫生];

学科分类号：

10 [医学];

摘要：

We investigated whether the Chinese herbal remedy, Hachimi-jio-gan extract, attenuates the renal injury seen in salt-induced hypertension in Dahl salt-sensitive (Dahl S) rats. Administration of this extract for 5 weeks dose-dependently decreased systolic blood pressure in Dahl S rats fed with a high-salt (2% NaCl) diet. This blood pressure reduction was associated with a decrease in cardiac mass and in thickness of the aortic wall. Urinary excretion of prostaglandin E(2) was increased and glomerular filtration rate was improved with this treatment. Glomerulosclerosis and arterial injury in the kidney were morphologically improved, These data suggest that Hachimi-jio-gan extract exhibits an antihypertensive effect, which is associated with partial resolution of renal injury in salt-induced hypertension.

引用

页码：241 / 254

页数：14

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