A short assessment of sublingual immunotherapy

The WHO has recommended sublingual immunotherapy (SLIT) as the suitable treatment for allergic rhinitis in adults [I]. Our article is based on 220 double-blind, placebo-controlled studies published in peer-reviewed international journals and our own experiences with this therapy in a controlled study with patients allergic to grass pollen [2]. Eighteen studies were performed in patients with rhinitis (table 1), two studies in patients with bronchial asthma [3, 4]. cumulative doses in biological units, others in micrograms of the major allergen Phl p 5. Bagnasco et al. [5] demonstrated with radioactively marked parietaria allergen that 2% of the allergen remained associated with the oral mucosa for 20 h. The radioactivity in the plasma increased after swallowing and peaked after 2 h. The rest of the material leaves the organism very quickly.