Imaging functional activation of the auditory cortex during focal repetitive transcranial magnetic stimulation of the primary motor cortex in normal subjects

被引：43

作者：

Siebner, HR

Peller, M

Willoch, F

Auer, C

Bartnestein, P

Drzezga, A

Schwaiger, M

Conrad, B

机构：

[1] Tech Univ Munich, Dept Neurol, D-81675 Munich, Germany

[2] Tech Univ Munich, Dept Nucl Med, D-81675 Munich, Germany

[3] Univ Oslo, Dept Pharmacol, N-0316 Oslo, Norway

来源：

NEUROSCIENCE LETTERS | 1999年 / 270卷 / 01期

关键词：

functional brain activation; primary motor cortex; auditory cortex; human; positron emission tomography; regional cerebral glucose metabolism; repetitive transcranial magnetic stimulation;

D O I：

10.1016/S0304-3940(99)00454-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Positron emission tomography (PET) during focal repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising approach to study cortical connectivity in awake humans. However, the noise caused by the discharging magnetic coil might have confounding effects on the rTMS-related cortical activation pattern. In twelve healthy volunteers, 1 8-fluoro-2-deoxy-D-glucose ((18)FDG) PET was employed to visualize the functional activation of the primary auditory cortex (PAC) during 2 Hz rTMS of the left primary sensorimotor hand area. Magnetic stimuli (1800) were applied at an intensity of 140% of motor resting threshold during the uptake period of (18)FDG. Though all subjects wore earplugs, rTMS-related noise induced a consistent bilateral increase of regional glucose utilization in the PAC(P < 0.05, corrected). Thus, rTMS-related acoustic input needs to be taken into account in combined rTMS/PET studies. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：37 / 40

页数：4

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