Inhibition of host cell signal transduction by Leishmania:: observations relevant to the selective impairment of IL-12 responses

被引：32

作者：

McDowell, MA ^{[1
]}

Sacks, DL ^{[1
]}

机构：

[1] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 1999年 / 2卷 / 04期

关键词：

D O I：

10.1016/S1369-5274(99)80077-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Leishmania parasites are able to delay the onset of cell-mediated immunity by selectively impairing the ability of infected macrophages to produce interleukin (IL)-12. Leishmania infection arrests the JAK/STAT-mediated signal transduction involved in activation of the IL-12 p40 promoter; the phosphorylation defects may be initiated by ligation of the phagocyte receptors used by these organisms to gain entry into the host cell.

引用

页码：438 / 443

页数：6

共 77 条

[1] Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes [J].