Breast cancer: Weighing the evidence for a promoting role of dietary fat

被引:136
作者
Wynder, EL
Cohen, LA
Muscat, JE
Winters, B
Dwyer, JT
Blackburn, G
机构
[1] TUFTS UNIV NEW ENGLAND MED CTR, BOSTON, MA 02111 USA
[2] DEACONESS HOSP, BOSTON, MA USA
来源
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1997年 / 89卷 / 11期
关键词
D O I
10.1093/jnci/89.11.766
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
It has been hypothesized that a high-fat diet promotes the development of postmenopausal breast cancer. This contention is supported by data showing high international correlations between fat intake and breast cancer rates, modest positive associations with a high-fat diet in case-control studies, and animal model studies that have consistently demonstrated that dietary fat influences mammary cancer development at several stages in the carcinogenic process. A number of plausible biologic mechanisms have been suggested that may explain such promotional effects. In contrast, dietary fat intake is unrelated to the risk of breast cancer in cohort studies. The conflicting findings from cohort studies have created uncertainty regarding nutritional recommendations and breast cancer prevention. After reviewing key scientific findings that are relevant to this issue, the following conclusion is drawn: In the absence of data from dietary intervention trials, the weight of available evidence suggests that the type and amount of fat in the diet is related to postmenopausal breast cancer and that the inability to detect associations within populations (cohort studies) is because of measurement error and the relative homogeneity of diets measured. It is expected that the results from intervention trials will clarify this issue.
引用
收藏
页码:766 / 775
页数:10
相关论文
共 177 条
[1]  
ABRAHAM S, 1983, J NATL CANCER I, V71, P601
[2]  
ADLERCREUTZ H, 1994, POLYCYCL AROMAT COMP, V6, P261, DOI 10.1080/10406639408031192
[3]  
ADLERCREUTZ H, 1988, PROGR CANC RES THERA, V35, P409
[4]  
[Anonymous], 1996, Lancet, V348, P1189
[5]   Dietary fat and risk of coronary heart disease in men: Cohort follow up study in the United States [J].
Ascherio, A ;
Rimm, EB ;
Giovannucci, EL ;
Spiegelman, D ;
Stampfer, M ;
Willett, WC .
BMJ-BRITISH MEDICAL JOURNAL, 1996, 313 (7049) :84-90
[6]   DIET AND FEMALE SEX-HORMONE CONCENTRATIONS - AN INTERVENTION STUDY FOR THE TYPE OF FAT CONSUMED [J].
BENNETT, FC ;
INGRAM, DM .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1990, 52 (05) :808-812
[7]   Serum sex hormone levels after menopause and subsequent breast cancer [J].
Berrino, F ;
Muti, P ;
Micheli, A ;
Bolelli, G ;
Krogh, V ;
Sciajno, R ;
Pisani, P ;
Panico, S ;
Secreto, G .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1996, 88 (05) :291-296
[8]   URINE NITROGEN AS AN INDEPENDENT VALIDATORY MEASURE OF DIETARY-INTAKE - A STUDY OF NITROGEN-BALANCE IN INDIVIDUALS CONSUMING THEIR NORMAL DIET [J].
BINGHAM, SA ;
CUMMINGS, JH .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1985, 42 (06) :1276-1289
[9]  
Black AE, 1996, NUTR REV, V54, P170, DOI 10.1111/j.1753-4887.1996.tb03924.x
[10]   SUGAR, MEAT, AND FAT INTAKE, AND NONDIETARY RISK-FACTORS FOR COLON-CANCER INCIDENCE IN IOWA WOMEN (UNITED-STATES) [J].
BOSTICK, RM ;
POTTER, JD ;
KUSHI, LH ;
SELLERS, TA ;
STEINMETZ, KA ;
MCKENZIE, DR ;
GAPSTUR, SM ;
FOLSOM, AR .
CANCER CAUSES & CONTROL, 1994, 5 (01) :38-52