An update on human and mouse glandular kallikreins

被引：31

作者：

Diamandis, EP

Yousef, GM

Olsson, AY

机构：

[1] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1L5, Canada

[3] Lund Univ, Univ Hosp MAS, Dept Lab Med, Div Clin Chem, Malmo, Sweden

来源：

CLINICAL BIOCHEMISTRY | 2004年 / 37卷 / 04期

关键词：

glandular kallikreins; human; mouse;

D O I：

10.1016/j.clinbiochem.2003.12.013

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Human glandular kallikreins are secreted serine proteases, involved in many biological processes. Recently, the complete organization of the human and mouse genomic loci has been elucidated. These loci harbor the largest clusters of serine proteases within the human and mouse genomes. Mouse orthologs to all human kallikrein genes, except for KLK2 and KLK3 genes, have now been identified. Here, we describe an update of the genomic organization of these families in human and mouse, and provide some thoughts for future research directions. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved.

引用

页码：258 / 260

页数：3

共 15 条

[1] Clinical value of human glandular kallikrein 2 and free and total prostate-specific antigen in serum from a population of men with prostate-specific antigen levels 3.0 ng/mL or greater [J].