The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence

被引：192

作者：

Lee, JY ^{[1
]}

Cannon, TW ^{[1
]}

Pruchnic, R ^{[1
]}

Fraser, MO ^{[1
]}

Huard, J ^{[1
]}

Chancellor, MB ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15213 USA

来源：

INTERNATIONAL UROGYNECOLOGY JOURNAL | 2003年 / 14卷 / 01期

关键词：

incontinence; leak point pressure; muscle-derived stem cells; rat;

D O I：

10.1007/s00192-002-1004-5

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Our goal was to determine whether periuirethral injection of allogenic muscle-derived stem cells (MDSC) Could increase the leak point pressure (LPP) in a denervated female rat model of stress urinary incontinence. Cells isolated from the gastrocnemius muscle of normal female rats were purified for a myogenic population by the preplate technique. Three experimental groups were established: a control group (C) had a sham operation without Injections; a sciatic nerve transection Group (D) had periurethral saline injections; and a sciatic nerve transsection group had periurethral MDSC injections (M). One week following treatment the LPP of groups C, D and M were 25.2 +/- 1.9 cmH(2)O, 28.6 +/- 0.8 cmH(2)O and 36.7 +/- 2.3 cmH(2)O respectively. At 4 weeks the LPP of groups C, D and M were 25.8 +/- 2.5 cmH(2)O, 18.6 +/- 5.2 cmH(2)O and 44.1 +/- 6.6 cmH(2)O, respectively. Allogenic MDSC significantly improved the LPP in sciatic nerve-transected animals after both 1 and 4 weeks compared to denervated animals injected with saline.

引用

页码：31 / 37

页数：7

共 32 条

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