Phosphoinositides in FCgamma receptor signaling

被引：3

作者：

Booth, JW

机构：

[1] Univ Toronto, Dept Immunol, Toronto, ON M4N 3M5, Canada

[2] Sunnybrook & Womens Res Inst, Toronto, ON M4N 3M5, Canada

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2006年 / 11卷

关键词：

phosphoinositide; Fc receptor; phagocytosis; ADCC; platelets; cytoskeleton; inflammation; CD16; CD32; CD64; review;

D O I：

10.2741/1879

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fcgamma receptors mediate a variety of immune responses to IgG-containing complexes. Virtually all of these responses appear to be regulated by phosphoinositides, in particular phosphatidylinositol (4,5)P-2 and phosphatidylinositol ( 3,4,5)P-3. Possible downstream effectors of phosphoinositides involved in multiple FcgammaR-mediated events are discussed, as are elements of the signaling pathways that may couple Fcgamma receptors to the enzymes of phosphoinositide metabolism.

引用

收藏

页码：1264 / 1274

页数：11

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