Recent developments in fragment-based drug discovery

[1] Ligand efficiency indices as guideposts for drug discovery [J]. DRUG DISCOVERY TODAY, 2005, 10 (07) : 464 - 469

[2] An integrated approach to fragment-based lead generation: Philosophy, strategy and case studies from AstraZeneca's drug discovery programmes [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2007, 7 (16) : 1600 - 1629

[3] Nitric oxide synthases: structure, function and inhibition [J]. BIOCHEMICAL JOURNAL, 2001, 357 (03) : 593 - 615

[4] Fragment-based drug discovery: What has it achieved so fair? [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2007, 7 (16) : 1544 - 1567

[5] Deconstructing fragment-based inhibitor discovery [J]. NATURE CHEMICAL BIOLOGY, 2006, 2 (12) : 720 - 723

[6] Fragment screening by biochemical assay [J]. EXPERT OPINION ON DRUG DISCOVERY, 2006, 1 (03) : 225 - 236

[7] Bartoli S, 2007, CURR OPIN DRUG DISC, V10, P422

[8] Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets [J]. JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2004, 44 (06): : 2157 - 2166

[9] New approach to molecular docking and its application to virtual screening of chemical databases [J]. JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2000, 40 (02): : 254 - 262

[10] BETZ M, 2007, CHEM BIOL SMALL MOL, P852

[1] Ligand efficiency indices as guideposts for drug discovery [J]. DRUG DISCOVERY TODAY, 2005, 10 (07) : 464 - 469

[2] An integrated approach to fragment-based lead generation: Philosophy, strategy and case studies from AstraZeneca's drug discovery programmes [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2007, 7 (16) : 1600 - 1629

[3] Nitric oxide synthases: structure, function and inhibition [J]. BIOCHEMICAL JOURNAL, 2001, 357 (03) : 593 - 615

[4] Fragment-based drug discovery: What has it achieved so fair? [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2007, 7 (16) : 1544 - 1567

[5] Deconstructing fragment-based inhibitor discovery [J]. NATURE CHEMICAL BIOLOGY, 2006, 2 (12) : 720 - 723

[6] Fragment screening by biochemical assay [J]. EXPERT OPINION ON DRUG DISCOVERY, 2006, 1 (03) : 225 - 236

[7] Bartoli S, 2007, CURR OPIN DRUG DISC, V10, P422

[8] Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets [J]. JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2004, 44 (06): : 2157 - 2166

[9] New approach to molecular docking and its application to virtual screening of chemical databases [J]. JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2000, 40 (02): : 254 - 262

[10] BETZ M, 2007, CHEM BIOL SMALL MOL, P852