Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder

被引:131
作者
MacKinnon, DF [1 ]
Zandi, PP [1 ]
Cooper, J [1 ]
Potash, JB [1 ]
Simpson, SG [1 ]
Gershon, E [1 ]
Nurnberger, J [1 ]
Reich, T [1 ]
DePaulo, JR [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21287 USA
关键词
D O I
10.1176/appi.ajp.159.1.30
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Panic attacks are a common complication of affective disorder, although the etiologic relationship of panic and affective symptoms has not been determined. Evidence from a family study suggests that panic attacks and panic disorder may be related genetically to bipolar disorder. This study used diagnostic data from the NIMH Bipolar Disorder Genetics Initiative to assess in a separate, larger family set the familiality of panic combined with bipolar disorder. Method: First-degree relatives (N=966) of probands with bipolar I disorder (N=192) and schizoaffective disorder, bipolar type, (N=11) were included in the study. All subjects were interviewed directly and were assigned best-estimate diagnoses for major affective and other psychiatric disorders. The risk of a family member being diagnosed with panic disorder if the proband with bipolar disorder had panic attacks or panic disorder was calculated with logistic regression analysis with generalized estimating equations that con-trolled for sex and affective disorder sub-diagnosis. Results: More than 90% of the probands and first-degree relatives with panic disorder also had an affective disorder diagnosis. Panic disorder was present in 17% of the relatives with recurrent major affective disorder and in 3% of the relatives without recurrent major affective disorder. Risk of panic disorder in relatives with bipolar disorder was increased significantly if the proband had panic attacks or panic disorder. Conclusions: Risk for panic disorder with familial bipolar disorder appears to be inherited. Inherited risk for panic disorder with bipolar disorder may indicate a shared genetic etiology for both disorders in some families. The patterns of bipolar disorder and panic disorder comorbidity observed in families imply a complex genetic etiology, which may be elucidated by using endophenotypes.
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页码:30 / 35
页数:6
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共 20 条
  • [1] CHEN YW, 1995, AM J PSYCHIAT, V152, P280
  • [2] CORYELL W, 1988, AM J PSYCHIAT, V145, P293
  • [3] The prevalence of comorbid anxiety in schizophrenia, schizoaffective disorder and bipolar disorder
    Cosoff, SJ
    Hafner, RJ
    [J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 1998, 32 (01) : 67 - 72
  • [4] EATON WW, 1994, AM J PSYCHIAT, V151, P413
  • [5] Anxiety as a correlate of response to the acute treatment of bipolar I disorder
    Feske, U
    Frank, E
    Mallinger, AG
    Houck, PR
    Fagiolini, A
    Shear, MK
    Grochocinski, VJ
    Kupfer, DJ
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (06) : 956 - 962
  • [6] Gorman JM, 1996, J CLIN PSYCHIAT, V57, P34
  • [7] LINKAGE OF EARLY-ONSET FAMILIAL BREAST-CANCER TO CHROMOSOME-17Q21
    HALL, JM
    LEE, MK
    NEWMAN, B
    MORROW, JE
    ANDERSON, LA
    HUEY, B
    KING, MC
    [J]. SCIENCE, 1990, 250 (4988) : 1684 - 1689
  • [8] Effects of stratification in the analysis of affected-sib-pair data: Benefits and costs
    Leal, SM
    Ott, J
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 66 (02) : 567 - 575
  • [9] REGRESSION-ANALYSIS FOR CORRELATED DATA
    LIANG, KY
    ZEGER, SL
    [J]. ANNUAL REVIEW OF PUBLIC HEALTH, 1993, 14 : 43 - 68
  • [10] MacKinnon DF, 1998, AM J PSYCHIAT, V155, P829