Sex differences in perihemorrhagic edema evolution after spontaneous intracerebral hemorrhage

被引：32

作者：

Wagner, I. ^{[1
]}

Volbers, B. ^{[1
]}

Kloska, S. ^{[2
]}

Doerfler, A. ^{[2
]}

Schwab, S. ^{[1
]}

Staykov, D. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Neurol, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Neuroradiol, D-91054 Erlangen, Germany

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2012年 / 19卷 / 11期

关键词：

gender; intracerebral hemorrhage; perihemorrhagic edema; BRAIN-INJURY; PERIHEMATOMAL EDEMA; CEREBRAL-ISCHEMIA; FOCAL ISCHEMIA; GENDER; STEROIDS; STROKE; RATS;

D O I：

10.1111/j.1468-1331.2011.03628.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose: Clinical data on sex differences in perihemorrhagic edema (PHE) after intracerebral hemorrhage (ICH) are lacking. Methods: Patients with spontaneous supratentorial ICH who had received standard conservative treatment were identified retrospectively. PHE development was assessed over a 14-day period on follow-up CT scans (days 1, 24, 57, 811, and 1214). ICH and PHE volumes were assessed semiautomatically and compared between men and women. Results: A total of 387 patients (233 men) were included. Starting at days 24, women showed lower PHE values (P < 0.05; days 24, 811) or a trend toward significance (P = 0.1; days 57, 1214). Conclusions: Female sex may predict lower PHE volumes.

引用

页码：1477 / 1481

页数：5

共 19 条

[1] Gender-linked brain injury in experimental stroke [J].

Alkayed, NJ ;

Harukuni, I ;

Kimes, AS ;

London, ED ;

Traystman, RJ ;

Hurn, PD .

STROKE, 1998, 29 (01) :159-165

[2] Neuroprotective effects of female gonadal steroids in reproductively senescent female rats [J].

Alkayed, NJ ;

Murphy, SJ ;

Traystman, RJ ;

Hurn, PD .

STROKE, 2000, 31 (01) :161-167

[3] Significance of perihematomal edema in acute intracerebral hemorrhage The INTERACT trial [J].

Arima, H. ;

Wang, J. G. ;

Huang, Y. ;

Heeley, E. ;

Skulina, C. ;

Parsons, M. W. ;

Peng, B. ;

Li, Q. ;

Su, S. ;

Tao, Q. L. ;

Li, Y. C. ;

Jiang, J. D. ;

Tai, L. W. ;

Zhang, J. L. ;

Xu, E. ;

Cheng, Y. ;

Morgenstern, L. B. ;

Chalmers, J. ;

Anderson, C. S. .

NEUROLOGY, 2009, 73 (23) :1963-1968

[4] EFFECT OF STEROIDS ON EDEMA AND SODIUM UPTAKE OF THE BRAIN DURING FOCAL ISCHEMIA IN RATS [J].

BETZ, AL ;

COESTER, HC .

STROKE, 1990, 21 (08) :1199-1204

[5] Genetic and gender influences on sensitivity to focal cerebral ischemia in the stroke-prone spontaneously hypertensive rat [J].

Carswell, HVO ;

Anderson, NH ;

Clark, JS ;

Graham, D ;

Jeffs, B ;

Dominiczak, AF ;

Macrae, IM .

HYPERTENSION, 1999, 33 (02) :681-685

[6] Elderly Women Regulate Brain Blood Flow Better Than Men Do [J].

Deegan, Brian M. ;

Sorond, Farzaneh A. ;

Galica, Andrew ;

Lipsitz, Lewis A. ;

O'Laighin, Gearoid ;

Serrador, Jorge M. .

STROKE, 2011, 42 (07) :1988-1993

[7] Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia [J].

Gibson, CL ;

Constantin, D ;

Prior, MJW ;

Bath, PMW ;

Murphy, SP .

EXPERIMENTAL NEUROLOGY, 2005, 193 (02) :522-530

[8] Estrogen Reduces Iron-Mediated Brain Edema and Neuronal Death [J].

Gu, Y. ;

Xi, G. ;

Liu, W. ;

Keep, R. F. ;

Hua, Y. .

BRAIN EDEMA XIV, 2010, 106 :159-162

[9] Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender [J].

Li, XL ;

Blizzard, KK ;

Zeng, ZY ;

DeVries, AC ;

Hurn, PD ;

McCullough, LD .

EXPERIMENTAL NEUROLOGY, 2004, 187 (01) :94-104

[10] Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion [J].

O'Donnell, Martha E. ;

Lam, Tina I. ;

Tran, Lien Q. ;

Foroutan, Shahin ;

Anderson, Steven E. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2006, 26 (10) :1234-1249

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