Atherosclerosis and the lectin-like OXidized low-density lipoprotein scavenger receptor

被引：66

作者：

Vohra, RS

Murphy, JE

Walker, JH

Ponnambalam, S

Homer-Vanniasinkam, S

机构：

[1] Gen Infirm, Leeds Vasc Inst, Leeds LS1 3EX, W Yorkshire, England

[2] Univ Leeds, Fac Biol Sci, Endothelial Cell Biol Unit, Leeds LS2 9JT, W Yorkshire, England

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2006年 / 16卷 / 02期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.tcm.2005.12.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Lectin-like OXidized low-density lipoprotein scavenger receptor (LOX-1) is implicated in vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization. LOX-1 levels are elevated upon recognition of oxidized low-density lipoprotein, a key pro-atherogenic substance in the vasculature. Recent evidence indicates this gene product is a biomarker of inflammation and disease status. We review and assess the role of LOX-1 in atherosclerotic plaque formation, physiologic regulation, and as a biomarker and target in cardiovascular disease diagnosis and prevention.

引用

收藏

页码：60 / 64

页数：5

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