Molecular controls of radiation-induced apoptosis in the neonatal rat kidney

被引：6

作者：

Gobé, G ^{[1
]}

Schoch, E ^{[1
]}

Leighton, J ^{[1
]}

机构：

[1] Univ Queensland, Sch Med, Dept Pathol, Brisbane, Qld 4006, Australia

来源：

KIDNEY INTERNATIONAL | 1999年 / 56卷 / 04期

关键词：

Bcl-2; p53; protein synthesis; cytoheximide; cell death; renal cancer;

D O I：

10.1046/j.1523-1755.1999.00686.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The incidence of cell death due to radiation was examined in a neonatal in vivo model. Differences in the induction of apoptosis, amount of cell proliferation, S-phase cell death, Bcl-2 and p-53 expression could best be explained by the differences in the zonal state of differentiation and development. The present in vivo model may thus be useful in testing radiation therapies for renal cancer.

引用

页码：1305 / 1309

页数：5

共 11 条

[1]

Buttyan R, 1997, Adv Pharmacol, V41, P369, DOI 10.1016/S1054-3589(08)61065-0

[2] CELL-DEATH BY APOPTOSIS FOLLOWING X-IRRADIATION OF THE FETAL AND NEONATAL RAT-KIDNEY [J].

GOBE, GC ;

AXELSEN, RA ;

HARMON, BV ;

ALLAN, DJ .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1988, 54 (04) :567-576

[3]

KAMADA S, 1995, CANCER RES, V55, P354

[4] APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS [J].

KERR, JFR ;

WYLLIE, AH ;

CURRIE, AR .

BRITISH JOURNAL OF CANCER, 1972, 26 (04) :239-+

[5]

KERR JFR, 1995, METHODS CELL BIOL CE, P1

[6] CANCER - P53, GUARDIAN OF THE GENOME [J].

LANE, DP .

NATURE, 1992, 358 (6381) :15-16

[7]

LU QL, 1994, J CELL SCI, V107, P362

[8] PROGRAMMED CELL-DEATH AND THE CONTROL OF CELL-SURVIVAL [J].

RAFF, MC ;

BARRES, BA ;

BURNE, JF ;

COLES, HSR ;

ISHIZAKI, Y ;

JACOBSON, MD .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1994, 345 (1313) :265-268

[9]

SAVILL J, 1994, J AM SOC NEPHROL, V5, P12

[10] Abnormal postpartum renal development and cystogenesis in the bcl-2(-/-)mouse [J].

Sorenson, CM ;

Padanilam, BJ ;

Hammerman, MR .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY, 1996, 271 (01) :F184-F193

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