Transition-Metal-Free Intermolecular Amination of sp3 C-H Bonds with Sulfonamides

被引：125

作者：

Fan, Renhua ^{[1
]}

Li, Weixun ^{[1
]}

Pu, Dongming ^{[1
]}

Zhang, Li ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ACTIVATED METHYLENE-COMPOUNDS; VINYLIC HALOGEN SUBSTITUTION; POLYVALENT IODINE COMPOUNDS; COPPER-CATALYZED AMIDATION; RADICAL CYCLIZATION; ORGANOHYPERVALENT IODINE; INDUCED AZIRIDINATION; RUTHENIUM PORPHYRINS; AMIDYL RADICALS; MILD CONDITIONS;

D O I：

10.1021/ol900090f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient transition-metal-free intermolecular benzylic amidation with sulfonamides is described. Various valuable nitrogen-containing compounds, including amines, beta-chloro amine, amino alcohol, alpha-, beta-amino ester, and N-sulfonyl imine, are generated from the preferential N-functionalization of saturated benzylic C-H bonds. The potential of this reaction system also lies in the fact it can be developed into an environmentally friendly intermolecular amidation process.

引用

页码：1425 / 1428

页数：4

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