The HLA complex in Goodpasture's disease: A model for analyzing susceptibility to autoimmunity

被引：121

作者：

Phelps, RG ^{[1
]}

Rees, AJ ^{[1
]}

机构：

[1] Univ Aberdeen, Dept Med & Therapeut, Aberdeen, Scotland

来源：

KIDNEY INTERNATIONAL | 1999年 / 56卷 / 05期

关键词：

DRB1; alleles; autoimmune disease; immune system; glomerulonephritis; meta-analysis; peptides; HLA class II molecules;

D O I：

10.1046/j.1523-1755.1999.00720.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Human lymphocyte antigen (HLA) associations are recognized for many autoimmune diseases, but the mechanisms are not clear. Goodpasture's disease provides a unique opportunity to investigate possible mechanisms because strong HLA associations are known, the autoantigen is well defined, and major antigen-derived peptides presented bound to KLA molecules have been identified. Therefore, it map be possible to directly analyze interactions between the antigen and KLA molecules associated with the disease, and to examine influences on antigen presentation to T cells. Towards this goal, we present a detailed analysis of HLA associations with the disease and examine molecular mechanisms that could account for them.

引用

页码：1638 / 1653

页数：16

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