Colon-specific delivery of budesonide with azopolymer-coated pellets: Therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats

被引:32
作者
Tozaki, H
Fujita, T [1 ]
Komoike, J
Kim, SI
Terashima, H
Muranishi, S
Okabe, S
Yamamoto, A
机构
[1] Kyoto Pharmaceut Univ, Dept Biopharmaceut, Yamashina Ku, Kyoto 6078414, Japan
[2] Kyoto Pharmaceut Univ, Dept Appl Pharmacol, Yamashina Ku, Kyoto 6078414, Japan
[3] ONO Pharmaceut Co Ltd, Shimamoto, Osaka 618, Japan
关键词
D O I
10.1211/0022357991772420
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The objective of this study was to achieve colon-specific delivery of budesonide using azopolymer-coated pellets and to accelerate healing of 2,4,6-trinitrobenzenesulphonic acid sodium salt (TNBS)-induced colitis in rats. After oral administration of azopolymer-coated pellets containing budesonide, a significant increase was observed in the therapeutic effects of the drug accompanied by a decrease in its systemic adverse effects when compared with oral administration in saline or rectal administration by enema. In addition, with the use of the colon-specific oral dosage form the dose of budesonide could be reduced. These results suggested that azopolymer-coated pellets may be a useful dosage form for the colon-specific delivery of budesonide as an anti-inflammatory steroid drug to bring about the healing of TNBS-induced colitis in rats.
引用
收藏
页码:257 / 261
页数:5
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