Determination of tungsten in bulk drug substance and intermediates by ICP-AES and ICP-MS

被引：23

作者：

Wang, TB

Ge, ZH

Wu, J

Li, B

Liang, AS

机构：

[1] Merck Res Labs, Analyt Res Dept, Rahway, NJ 07065 USA

[2] Merck Mfg Div, Qual Control, Rahway, NJ 07065 USA

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1999年 / 19卷 / 06期

关键词：

tungsten analysis; bulk drug substance and intermediates; inductively coupled plasma atomic emission spectroscopy; inductively coupled plasma mass spectroscopy;

D O I：

10.1016/S0731-7085(98)00259-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A quick and sensitive method has been developed and validated for the determination of tungsten in bulk drug substance and intermediates using either Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Sample preparation is by direct dissolution with a 80:20 (v/v) concentrated nitric acid:deionized water mixture and avoids labor intensive and potentially hazardous digestion techniques. Excellent agreement was found between ICP-AES and ICP-MII results and between Merck results and Microwave Induced Plasma Mass Spectrometry (MIP-MS) results provided by an independent raw material vendor. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：937 / 943

页数：7

共 16 条

[1] ATOMIC-ABSORPTION SPECTROMETRIC MICRODETERMINATION OF TUNGSTEN(VI) IN ALLOYS AND ENVIRONMENTAL-SAMPLES AFTER EXTRACTIVE SEPARATION WITH A HYDROXAMIC ACID INTO MIBK [J].