Grouping for behavioral and psychological symptoms in dementia: clinical and biological aspects. Consensus paper of the European Alzheimer disease consortium

被引:146
作者
Robert, PH
Verhey, FRJ
Byrne, EJ
Hurt, C
De Deyn, PP
Nobili, F
Riello, R
Rodriguez, G
Frisoni, GB
Tsolaki, M
Kyriazopoulou, N
Bullock, R
Burns, A
Vellas, B
机构
[1] Univ Nice, CHU, Pasteur Hosp, Ctr Memoire Ressources & Rech, F-06002 Nice, France
[2] Univ Hosp Maastricht, Alzheimer Ctr, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
[3] Univ Manchester, Sch Psychiat, Manchester M13 9PL, Lancs, England
[4] Univ Antwerp, Dept Neurol, B-2020 Antwerp, Belgium
[5] Univ Antwerp, Dept Biomed Sci, B-2020 Antwerp, Belgium
[6] Univ Genoa, Dept Endocrinol & Metab, Genoa, Italy
[7] IRCCS, Lab Epidemiol & Neuroimaging, Brescia, Italy
[8] Dept Neurol, Thessaloniki, Greece
[9] Victoria Hosp, Kingshill Res Ctr, Swindon, Wilts, England
[10] Ctr Mem Ressources & Rech, Toulouse, France
关键词
dementia; Alzheimer's disease; behavioral disturbances;
D O I
10.1016/j.eurpsy.2004.09.031
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Behavioral and psychological symptoms of dementia (BPSD), constitute a major clinical component of Alzheimer's disease (AD). There is a growing interest in BPSD as they are responsible for a large share of the suffering of patients and caregivers, and they strongly determine the patient's lifestyle and management. Better detection and understanding of these symptoms is essential to provide appropriate management. This article is a consensus produced by the behavioral group of the European Alzheimer's Disease Consortium (EADC). The aim of this article is to present clinical description and biological correlates of the major behavioral and psychological symptomatology in AD. BPSD is not a unitary concept. Instead, it should be divided into several symptoms or more likely: groups of symptoms, each possibly reflecting a different prevalence, course over time, biological correlate and psychosocial determinants. There is some clinical evidence for clusters within groups of BPSD. Biological studies indicate that patients with AD and BPSD are associated with variations in the pathological features (atrophy, brain perfusion/metabolism, histopathology) when compared to people with AD without BPSD. An individually tailored approach taking all these aspects into account is warranted as it may offer more, and better, pharmacological and non-pharmacological treatment opportunities. (c) 2005 Elsevier SAS. All rights reserved.
引用
收藏
页码:490 / 496
页数:7
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