Transducing signals of life and death

被引：244

作者：

Yuan, JY

机构：

[1] Department of Cell Biology, Harvard Medical School, Boston, MA 02115

来源：

CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0955-0674(97)80069-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The molecules that form signaling complexes with the cytoplasmic domains of tumor necrosis factor (TNF) receptors (TNF-Rs) and CD95 have been identified recently. The death-signaling pathways induced by TNF-R1 and CD95 involve a group of death domain containing proteins, including caspase-8, a member of the interleukin-1 beta-converting enzyme family. TNF-R1 and TNF-R2 also interact with the members of both the TNF-R associated factor family and the inhibitor of apoptosis protein family; these interactions lead to cell survival.

引用

收藏

页码：247 / 251

页数：5

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