Specific crosslinking of cell adhesive molecules by heterobifunctional glycopeptide synthesised on the basis of chemoenzymatic strategy

被引：8

作者：

Nishimura, SI ^{[1
]}

Matsuda, M

Kitamura, H

Nishimura, T

机构：

[1] Hokkaido Univ, Grad Sch Sci, Div Biol Sci, Lab Biomacromol Chem, Sapporo, Hokkaido 0600810, Japan

[2] Tokai Univ, Sch Med, Dept Immunol, Div Host Def Mechanisms, Isehara, Kanagawa 2591193, Japan

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 15期

关键词：

D O I：

10.1039/a904362d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Heterobifunctional glycopeptide 1 composed of Neu5Ac alpha-(2 --> 3)Gal beta(1 --> 4)[Fuc alpha(1 --> 3)]GlcNAc (sialyl Lewis(x)) and Lys-Gly-Arg-Gly-Asp-Ser (KGRGDS) having specific activity to bind concurrently with two different types of cell adhesive molecules such as selectins and integrins was synthesised on the basis of a combined chemical and enzymatic strategy.

引用

收藏

页码：1435 / 1436

页数：2

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