Intestinal microbiota and ulcerative colitis

被引：147

作者：

Ohkusa, Toshifumi ^{[1
]}

Koido, Shigeo ^{[1
]}

机构：

[1] Jikei Univ, Kashiwa Hosp, Dept Gastroenterol & Hepatol, Kashiwa, Chiba 2778567, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2015年 / 21卷 / 11期

关键词：

Bacteria; Intestinal microbiota; Innate immunity; Inflammatory bowel disease; Ulcerative colitis; Crohn's disease; INFLAMMATORY-BOWEL-DISEASE; ANTIBIOTIC COMBINATION THERAPY; TOLL-LIKE RECEPTOR-2; NEONATAL NECROTIZING ENTEROCOLITIS; MUCOSA-ASSOCIATED MICROBIOTA; BUTYRATE-PRODUCING BACTERIA; ESCHERICHIA-COLI; FECAL MICROBIOTA; CROHNS-DISEASE; KAPPA-B;

D O I：

10.1016/j.jiac.2015.07.010

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

There is a close relationship between the human host and the intestinal microbiota, which is an assortment of microorganisms, protecting the intestine against colonization by exogenous pathogens. Moreover, the intestinal microbiota play a critical role in providing nutrition and the modulation of host immune homeostasis. Recent reports indicate that some strains of intestinal bacteria are responsible for intestinal ulceration and chronic inflammation in inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD). Understanding the interaction of the intestinal microbiota with pathogens and the human host might provide new strategies treating patients with IBD. This review focuses on the important role that the intestinal microbiota plays in maintaining innate immunity in the pathogenesis and etiology of UC and discusses new antibiotic therapies targeting the intestinal microbiota. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：761 / 768

页数：8

共 76 条

[1]

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 [J].

Aliprantis, AO ;

Yang, RB ;

Mark, MR ;

Suggett, S ;

Devaux, B ;

Radolf, JD ;

Klimpel, GR ;

Godowski, P ;

Zychlinsky, A .

SCIENCE, 1999, 285 (5428) :736-739

[2]

Terminal restriction fragment length polymorphism analysis of the diversity of fecal microbiota in patients with ulcerative colitis [J].

Andoh, Akira ;

Sakata, Shinji ;

Koizumi, Yuhsuke ;

Mitsuyama, Keiichi ;

Fujiyoma, Yoshihide ;

Benno, Yoshimi .

INFLAMMATORY BOWEL DISEASES, 2007, 13 (08) :955-962

[3]

Identification of enterohepatic Helicobacter species in patients suffering from inflammatory bowel disease [J].

Bohr, URM ;

Glasbrenner, B ;

Primus, A ;

Zagoura, A ;

Wex, T ;

Malfertheiner, P .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (06) :2766-2768

[4]

EXPERIMENTAL CECITIS IN GNOTOBIOTIC QUAILS MONOASSOCIATED WITH CLOSTRIDIUM-BUTYRICUM STRAINS ISOLATED FROM PATIENTS WITH NEONATAL NECROTIZING ENTEROCOLITIS AND FROM HEALTHY NEWBORNS [J].

BOUSSEBOUA, H ;

LECOZ, Y ;

DABARD, J ;

SZYLIT, O ;

RAIBAUD, P ;

POPOFF, MR ;

RAVISSE, P .

INFECTION AND IMMUNITY, 1989, 57 (03) :932-936

[5]

ADHESIVE ESCHERICHIA-COLI IN INFLAMMATORY BOWEL-DISEASE AND INFECTIVE DIARRHEA [J].

BURKE, DA ;

AXON, ATR .

BMJ-BRITISH MEDICAL JOURNAL, 1988, 297 (6641) :102-104

[6]

Dianda L, 1997, AM J PATHOL, V150, P91

[7]

Butyricicoccus pullicaecorum in inflammatory bowel disease [J].

Eeckhaut, Venessa ;

Machiels, Kathleen ;

Perrier, Clementine ;

Romero, Carlos ;

Maes, Sofie ;

Flahou, Bram ;

Steppe, Marjan ;

Haesebrouck, Freddy ;

Sas, Benedikt ;

Ducatelle, Richard ;

Vermeire, Severine ;

Van Immerseel, Filip .

GUT, 2013, 62 (12) :1745-1752

[8]

Longitudinal Analyses of Gut Mucosal Microbiotas in Ulcerative Colitis in Relation to Patient Age and Disease Severity and Duration [J].

Fite, Alemu ;

Macfarlane, Sandra ;

Furrie, Elizabeth ;

Bahrami, Bahram ;

Cummings, John H. ;

Steinke, Douglas T. ;

Macfarlane, George T. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (03) :849-856

[9]

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases [J].

Frank, Daniel N. ;

Amand, Allison L. St. ;

Feldman, Robert A. ;

Boedeker, Edgar C. ;

Harpaz, Noam ;

Pace, Norman R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (34) :13780-13785

[10]

Quantitative analysis of bacterial DNA from Mycobacteria spp., Bacteroides vulgatus, and Escherichia coli in tissue samples from patients with inflammatory bowel diseases [J].

Fujita, H ;

Eishi, Y ;

Ishige, I .

JOURNAL OF GASTROENTEROLOGY, 2002, 37 (07) :509-516

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