Cardiovascular effects of aldosterone and post-acute myocardial infarction pathophysiology

被引:58
作者
Cohn, JN
Colucci, W
机构
[1] Univ Minnesota, Sch Med, Dept Med, Div Cardiovasc, Minneapolis, MN 55455 USA
[2] Boston Univ, Med Ctr, Sect Cardiovasc Med, Boston, MA 02215 USA
关键词
D O I
10.1016/j.amjcard.2006.03.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aldosterone is an important mediator of the renin-angiotensin-aldosterone system (RAAS) that plays a major role in the pathophysiology of cardiovascular disease as well as regulation of extracellular fluid volume and potassium. In experimental models, aldosterone has been shown to promote endothelial dysfunction; induce vascular inflammation, myocardial ischemia, and necrosis; increase collagen synthesis in cardiac fibroblasts; contribute to plasminogen activator inhibitor-1 regulation; decrease baroreceptor sensitivity and reflex function; block myocardial uptake of norepinephrine; increase oxidative stress; and stimulate cardiomyocyte apoptosis. A review of animal and human studies with, aldosterone blockers reveals improvement in, and in some cases complete reversal of, these pathophysiologic effects of aldosterone on the cardiovascular system.
引用
收藏
页码:4F / 12F
页数:9
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