CTX-M-14, a plasmid-mediated CTX-M type extended-spectrum β-lactamase isolated from Escherichia coli

被引：49

作者：

Ma, L

Ishii, Y

Chang, FY

Yamaguchi, K

Ho, M

Siu, LK

机构：

[1] Natl Hlth Res Inst, Div Clin Res, Taipei 11529, Taiwan

[2] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Div Infect Dis & Trop Med, Taipei, Taiwan

[3] Toho Univ, Sch Med, Dept Microbiol, Tokyo, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 06期

关键词：

D O I：

10.1128/AAC.46.6.1985-1988.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Four Escherichia coli isolates harboring CTX-M-14, with a single Ala231-->Val substitution compared to CTX-M-9, had three different ribotypes. Cefotaxime resistance was plasmid encoded and conjugatively transferable. Three isolates had the same plasmid restriction enzyme digestion profile, suggesting clonal spread of a resistant plasmid. A high k(cat)/K-m value for cefotaxime (20.3 muM(-1) s(-1)) but low values for ceftazidime and aztreonam (<0.02 muM(-1) s(-1)) were observed in hydrolysis assays, indicating resistance to cefotaxime (MIC 64 mug/ml) but susceptibility to ceftazidime (MIC less than or equal to 2 mug/ml).

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页码：1985 / 1988

页数：4

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