Xid and Xid-like immunodeficiencies from a signaling point of view

被引：21

作者：

Tarakhovsky, A

机构：

[1] Institute for Genetics, Univ. Cologne, Weyertal 121, 50931, Cologne

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(97)80076-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The analysis of Btk-associated molecules and ligand-induced Btk phosphorylation has suggested the existence of a complexed Btk-associated signaling network involved in the activation of B lymphocytes and mast cells. Recent gene targeting experiments have revealed protein kinase C beta I/II (PKC beta I/II) as a critical component of the Btk-dependent signaling chain and have highlighted a potential role for the Btk-PKC beta I/II interaction in the amplification of B cell receptor mediated signaling.

引用

收藏

页码：319 / 323

页数：5

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