Post-methionine load test: A more sensitive tool to reveal hyperhomocystememia in Alzheimer patients?

被引：11

作者：

Galimberti, Gloria ^{[1
,2
]}

Conti, Elisa ^{[1
,2
]}

Zin, Michela ^{[1
,3
]}

Piazza, Fabrizio ^{[1
]}

Fenaroli, Francesco ^{[4
]}

Isella, Valeria ^{[1
,3
]}

Facheris, Maurizio ^{[1
,3
]}

Perlangeli, Vittoria ^{[5
]}

Antolini, Laura ^{[6
]}

DeFilippi, Francesco ^{[4
]}

Ferrarese, Carlo ^{[1
,2
,3
]}

机构：

[1] Univ Milan, Dept Neurosci & Biomed Technol, I-20052 Monza, MI, Italy

[2] Sci Inst E Medea, I-23842 Bosisio Parini, LC, Italy

[3] San Gerardo Hosp, Dept Neurol, I-20052 Monza, MI, Italy

[4] San Gerardo Hosp, Div Geriatr, I-20052 Monza, MI, Italy

[5] San Gerardo Hosp, Lab Anal, I-20052 Monza, MI, Italy

[6] Univ Milan, Dept Clin Med & Prevent, I-20052 Monza, MI, Italy

来源：

CLINICAL BIOCHEMISTRY | 2008年 / 41卷 / 10-11期

关键词：

homocysteme; post-methionine load test; folate lowering therapy; Alzheimer's disease;

D O I：

10.1016/j.clinbiochem.2008.03.015

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy. Methods: Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system. Results: PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis. Conclusion: PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：914 / 916

页数：3

共 12 条

[1] Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: An overview [J].

Castro, R ;

Rivera, I ;

Blom, HJ ;

Jakobs, C ;

de Almeida, IT .

JOURNAL OF INHERITED METABOLIC DISEASE, 2006, 29 (01) :3-20

[2] Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials [J].

Clarke, R ;

Frost, C ;

Sherliker, P ;

Lewington, S ;

Collins, R ;

Brattstrom, L ;

Brouwer, I ;

van Dusseldorp, M ;

Steegers-Theunissen, RPM ;

Cuskelly, G ;

Ward, M ;

McNulty, H ;

Scott, J ;

den Heijer, M ;

Blom, H ;

van der Put, N ;

Shorah, CJ ;

Malinow, MR ;

McMahon, M ;

Tobert, J ;

Kush, D ;

Joosten, E ;

Riezier, R ;

Pietrzik, K ;

Dierkes, J ;

Bronstrup, A ;

Jacques, P ;

Mason, J ;

Rosenberg, I ;

Thambyrajah, J ;

Landray, M ;

Townend, J ;

Wheeler, D ;

Ubbink, J ;

van Oort, F ;

Melse-Boonstra, A ;

Verhoef, P ;

Woodside, JV ;

Yarnell, J ;

Young, IS ;

Evans, AE ;

Wald, D ;

Law, M ;

Wald, N .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 82 (04) :806-812

[3] Evaluation of a shorter methionine loading test [J].

de Jonge, R ;

Griffioen, PH ;

van Zelst, B ;

Brouns, RM ;

Visser, W ;

Lindemans, J .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2004, 42 (09) :1027-1031

[4] Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging [J].

Haan, Mary N. ;

Miller, Joshua W. ;

Aiello, Allison E. ;

Whitmer, Rachel A. ;

Jagust, William J. ;

Mungas, Dan M. ;

Allen, Lindsay H. ;

Green, Ralph .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 85 (02) :511-517

[5]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[6] Total plasma homocysteine values among elderly subjects: Findings ftom the Maracaibo Aging Study [J].

Molero, Aldrin E. ;

Altimari, Cannen C. ;

Duran, Dariana A. ;

Garcia, Esperanza ;

Pino-Ramirez, Gloria ;

Maestre, Gladys E. .

CLINICAL BIOCHEMISTRY, 2006, 39 (10) :1007-1015

[7]

Pietrzik K, 1997, INT J VITAM NUTR RES, V67, P389

[8] Total homocysteine measurement in clinical practice [J].

Rasmussen, K ;

Moller, J .

ANNALS OF CLINICAL BIOCHEMISTRY, 2000, 37 :627-648

[9] Homocysteine and folate as risk factors for dementia and Alzheimer disease [J].

Ravaglia, G ;

Forti, P ;

Maioli, F ;

Martelli, M ;

Servadei, L ;

Brunetti, N ;

Porcellini, E ;

Licastro, F .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 82 (03) :636-643

[10]

Seshadri S, 2006, J ALZHEIMERS DIS, V9, P393

← 1 2 →