Mutasynthesis of Fluorinated Pactamycin Analogues and Their Antimalarial Activity

被引：35

作者：

Almabruk, Khaled H. ^{[1
]}

Lu, Wanli ^{[1
]}

Li, Yuexin ^{[2
]}

Abugreen, Mostafa ^{[1
]}

Kelly, Jane X. ^{[2
]}

Mahmud, Taifo ^{[1
]}

机构：

[1] Oregon State Univ, Dept Pharmaceut Sci, Corvallis, OR 97331 USA

[2] Vet Affairs Med Ctr, Portland, OR 97239 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 07期

关键词：

STREPTOMYCES-PACTUM; BIOSYNTHESIS;

D O I：

10.1021/ol4004614

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A mutasynthetic strategy has been used to generate fluorinated TM-025 and TM-026, two biosynthetically engineered pactamycin analogues produced by Streptomyces pactum ATCC 27456. The fluorinated compounds maintain excellent activity and selectivity toward chloroquine-sensitive and multidrug-resistant strains of malarial parasites as the parent compounds. The results also provide insights into the biosynthesis of 3-aminobenzoic acid in S. pactum.

引用

页码：1678 / 1681

页数：4

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