Structural and antitumor activity study of γ-octamolybdates containing aminoacids and peptides

gamma-Type octarnolybdates of the formulae, Na-4[Mo8O26(alaO)(2)] center dot 18H(2)O (I), Na-4[Mo8O26(glyglyO)(2)]1Y0) center dot 15H(2)O (II) and Na-4[Mo8O26(gly-glyO)(2)] center dot 12H(2)O (III) have been prepared from sodium molybdate in aqueous solution by adding DL-alanine or glycylglycine. Their crystal structures have been determined by X-ray structure analysis. DL-alanine and glycylglycine coordinate molybdenum atom ill gamma-octamolybdate [Mo8O26](4-) anions via monodentate carboxylate-oxygen atom. The prepared octamolybdates were screened for the possible antiproliferative activity oil a panel of five tumor cell lines and on a normal cell line. All tested compounds showed a differential cell-growth inhibition in a dose-dependent manner selectively oil hepatocellular carcinoma cell line (HepG2) and breast cancercell line (MCF-7). (c) 2005 Elsevier B.V. All rights reserved.