Junctions as organizing centers in epithelial cells? A fly perspective

被引：28

作者：

Lecuit, T ^{[1
]}

Wieschaus, E ^{[1
]}

机构：

[1] Princeton Univ, Howard Hughes Med Inst, Dept Biol Mol, Princeton, NJ 08544 USA

来源：

TRAFFIC | 2002年 / 3卷 / 02期

关键词：

asymmetric cell division; cellularization; Drosophila; junctions; membrane growth; polarity;

D O I：

10.1034/j.1600-0854.2002.030202.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such as the orientation of the division apparatus.

引用

页码：92 / 97

页数：6

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