Antibiotics A21459 A and B, new inhibitors of bacterial protein synthesis .2. Structure elucidation

被引：27

作者：

Ferrari, P ^{[1
]}

Vekey, K ^{[1
]}

Galimberti, M ^{[1
]}

Gallo, GG ^{[1
]}

Selva, E ^{[1
]}

Zerilli, LF ^{[1
]}

机构：

[1] MARION MERRELL DOW RES INST,LEPETIT RES CTR,GERENZANO,VA,ITALY

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 02期

关键词：

D O I：

10.7164/antibiotics.49.150

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of the antibiotics, active against a few Gram-negative bacteria and Clostridium difficile, were determined on the basis of physicochemical analyses on the intact molecules and on the acid hydrolysate of A21459 A. FAB-MS and H-1 and C-13 NMR investigations identified the amino acid units and determined their sequence. Antibiotics A21459 A and B are homodetic cyclic peptides constituted by eight amino acid units. They are glycine, methoxytryptophan, tryptophan, cysteine, alanine, sarcosine, dehydroalanine, and alpha-aminobutyric acid for A21459 A (alanine for A21459 B). Cysteine and alanine condensed to form a thiazole moiety, according to the biosynthesis of thiazole containing antibiotics.

引用

页码：150 / 154

页数：5

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