Biddable death

被引：30

作者：

Nagata, S

机构：

[1] Osaka Univ, Sch Med, Dept Genet, Osaka 5650871, Japan

[2] Osaka Univ, Sch Med, CREST, Osaka 5650871, Japan

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 06期

关键词：

D O I：

10.1038/14094

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mice lacking the pro-apototic protein Bid are resistant to the lethal effects of 'death-factor' signals relayed through Fas. But whereas Bid-deficient hepatocytes are resistant to Fas-mediated apoptosis, thymocytes and embryonal fibroblasts are not. This confirms the cell-type specificity of the Bid-dependent mitochondrial apoptotic pathway.

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收藏

页码：E143 / E145

页数：3

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