ROLES OF CELLULAR POLYAMINES IN MUCOSAL HEALING IN THE GASTROINTESTINAL TRACT

被引：13

作者：

Gao, J. -H. ^{[1
,2
]}

Guo, L. -J. ^{[2
]}

Huang, Z. -Y. ^{[2
]}

Rao, J. N. ^{[3
]}

Tang, C. -W. ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Div Peptides Related Human Dis, State Key Lab Biotherapy, Chengdu 610064, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Gastroenterol, Chengdu 610041, Peoples R China

[3] Univ Maryland, Sch Med, Baltimore VA Med Ctr, Dept Surg, Baltimore, MD 21201 USA

来源：

JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2013年 / 64卷 / 06期

关键词：

angiogenesis; apoptosis; barrier function; ornithine decarboxylase; polyamines; proliferation; stern cells; restitution; INTESTINAL EPITHELIAL-CELLS; INFLAMMATORY-BOWEL-DISEASE; HEPATOCYTE GROWTH-FACTOR; BINDING PROTEIN HUR; ORNITHINE-DECARBOXYLASE ACTIVITY; KAPPA-B ACTIVATION; HELICOBACTER-PYLORI; MESSENGER-RNA; STEM-CELLS; BARRIER DYSFUNCTION;

D O I：

暂无

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

The mammalian gastrointestinal (GI) mucosa is a rapidly self-renewing tissue in the body, and its integrity is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. Polyamines are shown to play an important role in the regulation of gastrointestinal mucosal growth and healing after injury under physiological and various pathological conditions. In this review, we highlight the importance of cellular polyamines in the control GI mucosal proliferation, migration, apoptosis, angiogenesis and GI barrier function during mucosal repair after injury.

引用

页码：681 / 693

页数：13

共 194 条

[1]

ABDULHUSSEIN AA, 2013, AMINO ACIDS

[2]

Ahluwalia A, 2011, J PHYSIOL PHARMACOL, V62, P583

[3]

Effect of ulceration on rat gastric tissue polyamine contents in response to different procedures; inhibition of these effects by cimetidine [J].