Use of DNA arrays/microarrays in pancreatic research

被引：14

作者：

Buchholz, M ^{[1
]}

Boeck, W ^{[1
]}

Fensterer, H ^{[1
]}

Müller, F ^{[1
]}

Wenger, C ^{[1
]}

Michl, P ^{[1
]}

Adler, G ^{[1
]}

Gress, TM ^{[1
]}

机构：

[1] Univ Ulm, Dept Internal Med 1, D-89081 Ulm, Germany

来源：

PANCREATOLOGY | 2001年 / 1卷 / 06期

关键词：

microarray; expression profiling; pancreatic cancer;

D O I：

10.1159/000055867

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In recent years, enormous technical advances in experimental protocols as well as robotic and bioinformatic techniques have allowed DNA array/microarray technology to emerge as the leading technology in the field of functional, disease-related genome analysis. Multiple applications exist for DNA arrays/microarrays including comparative genomic analysis to identify chromosomal imbalances (Matrix-CGH), the study of mutations and genetic polymorphisms, and the study of gene expression (expression profiling). Expression profiling is the most widely used application of DNA array/microarray technology and allows to measure gene expression of thousands of genes simultaneously. The present reviews describes the basic principles of expression profiling analyses and outlines some applications in pancreatic cancer research. Copyright (C) 2001 S. Karger AG, Basel and IAP.

引用

页码：581 / 586

页数：6

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