Clinical relevance of cyclin B1 overexpression in laryngeal squamous cell carcinoma

被引：78

作者：

Dong, YY ^{[1
]}

Sui, L ^{[1
]}

Watanabe, Y ^{[1
]}

Sugimoto, K ^{[1
]}

Tokuda, M ^{[1
]}

机构：

[1] Kagawa Med Univ, Dept Physiol, Miki, Kagawa 7610793, Japan

来源：

CANCER LETTERS | 2002年 / 177卷 / 01期

关键词：

cyclin B1; larynx; squamous cell carcinoma;

D O I：

10.1016/S0304-3835(01)00770-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cyclin B1 is a key molecule for G2/M phase transition during the cell cycle and is overexpressed in various human tumors. However, the expression status of cyclin B I in laryngeal squamous cell carcinoma (LSCC) and its clinical significance remain unknown. We used inummohistochemical studies to examine the expression of cyclin B1 in 102 patients with LSCC. The results showed that cyclin B1 overexpression was observed in 40 cases (39.2%) of LSCCs and was significantly correlated with the tumor site (P = 0.031), tumor size (P < 0.0001), and advanced stage (P = 0.003). In addition, cyclin B1 overexpression was associated with patients' overall survival, but not with disease-free survival using Kaplan-Meier analysis. On multivariate analysis, cyclin B1 expression was not recognized as an independent prognostic factor. These findings indicate that cyclin B1 overexpression may be associated with the malignant biological behavior of LSCC. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：13 / 19

页数：7

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