The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

被引：1055

作者：

Mackay, Laura K. ^{[1
]}

Rahimpour, Azad ^{[1
]}

Ma, Joel Z. ^{[1
]}

Collins, Nicholas ^{[1
]}

Stock, Angus T. ^{[1
]}

Hafon, Ming-Li ^{[1
]}

Vega-Ramos, Javier ^{[1
]}

Lauzurica, Pilar ^{[2
]}

Mueller, Scott N. ^{[1
]}

Stefanovic, Tijana ^{[3
]}

Tscharke, David C. ^{[3
]}

Heath, William R. ^{[1
]}

Inouye, Michael ^{[1
,4
]}

Carbone, Francis R. ^{[1
]}

Gebhardt, Thomas ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

[2] Inst Salud Carlos III, Madrid, Spain

[3] Australian Natl Univ, Res Sch Biol, Div Biomed Sci & Biochem, Canberra, ACT, Australia

[4] Univ Melbourne, Dept Pathol, Melbourne, Vic, Australia

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 12期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

LYMPHOCYTE EGRESS; CD103; EXPRESSION; LOCAL IMMUNITY; CUTTING EDGE; RM CELLS; MIGRATION; EFFECTOR; ANTIGEN; DIFFERENTIATION; LOCALIZATION;

D O I：

10.1038/ni.2744

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Tissue-resident memory T cells (TRM cells) provide superior protection against infection in extralymphoid tissues. Here we found that CD103(+)CD8(+) TRM cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. A combination of entry into the epithelium plus local signaling by interleukin 15 (IL-15) and transforming growth factor-beta (TGF-beta) was required for the formation of these long-lived memory cells. Notably, differentiation into TRM cells resulted in the progressive acquisition of a unique transcriptional profile that differed from that of circulating memory cells and other types of T cells that permanently reside in skin epithelium. We provide a comprehensive molecular framework for the local differentiation of a distinct peripheral population of memory cells that forms a first-line immunological defense system in barrier tissues.

引用

页码：1294 / +

页数：10

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